Conventional and phase contrast x-ray imaging techniques and ultrasound imaging method in breast tumor detection: initial comparison studies using phantom

Yuran Guo; Di Wu; Farid H. Omoumi; Yuhua Li; Molly Donovan Wong; Muhammad U. Ghani; Bin Zheng; Hong Liu

doi:10.1117/12.2288555

19 February 2018 Conventional and phase contrast x-ray imaging techniques and ultrasound imaging method in breast tumor detection: initial comparison studies using phantom

Yuran Guo, Di Wu, Farid H. Omoumi, Yuhua Li, Molly Donovan Wong, Muhammad U. Ghani, Bin Zheng, Hong Liu

Author Affiliations +

Proceedings Volume 10495, Biophotonics and Immune Responses XIII; 1049513 (2018) https://doi.org/10.1117/12.2288555
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

The objective of this study was to demonstrate the capability of the high-energy in-line phase contrast imaging in detecting the breast tumors which are undetectable by conventional x-ray imaging but detectable by ultrasound. Experimentally, a CIRS multipurpose breast phantom with heterogeneous 50% glandular and 50% adipose breast tissue was imaged by high-energy in-line phase contrast system, conventional x-ray system and ultrasonography machine. The high-energy in-line phase contrast projection was acquired at 120 kVp, 0.3 mAs with the focal spot size of 18.3 μm. The conventional x-ray projection was acquired at 40 kVp, 3.3 mAs with the focal spot size of 22.26 μm. Both of the x-ray imaging acquisitions were conducted with a unique mean glandular dose of 0.08 mGy. As the result, the high-energy in-line phase contrast system was able to detect one lesion-like object which was also detected by the ultrasonography. This object was spherical shape with the length of about 12.28 mm. Also, the conventional x-ray system was not able to detect any objects. This result indicated the advantages provided by high-energy in-line phase contrast over conventional x-ray system in detecting lesion-like object under the same radiation dose. To meet the needs of current clinical strategies for high-density breasts screening, breast phantoms with higher glandular densities will be employed in future studies.

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Yuran Guo, Di Wu, Farid H. Omoumi, Yuhua Li, Molly Donovan Wong, Muhammad U. Ghani, Bin Zheng, and Hong Liu "Conventional and phase contrast x-ray imaging techniques and ultrasound imaging method in breast tumor detection: initial comparison studies using phantom", Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 1049513 (19 February 2018); https://doi.org/10.1117/12.2288555

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KEYWORDS

Phase contrast

Breast

Ultrasonography

X-ray imaging

Mammography

X-rays

Breast cancer

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