Pharmacokinetics Of Hematoporphyrine Derivative In The Normal And Carcinosarcoma Transplantated Organism

G. D. Litwin; R. D. Barabash; M. I. Petukhov; G. G. Ryansky; V. E. Normansky; K. P. Andreeva; A. S. Kolobanov

doi:10.1117/12.952049

11 September 1989 Pharmacokinetics Of Hematoporphyrine Derivative In The Normal And Carcinosarcoma Transplantated Organism

G. D. Litwin, R. D. Barabash, M. I. Petukhov, G. G. Ryansky, V. E. Normansky, K. P. Andreeva, A. S. Kolobanov

Author Affiliations +

Proceedings Volume 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems; (1989) https://doi.org/10.1117/12.952049
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

The fate of hematoporphyrin derivative (HpD, 10 mg/kg) was studied with microspectrofluorimetry in frozen tissue slices from female rats. In infact animals we observed the maximal incorporation of HpD in the small intestine mucosa, liver, lung, stomach and blad-der in 30 minutes, and in the skin and kidney - in 6 hours after an intravenous injection. In cancerous organism HpD was usually retained for 6-12 hours in different organs and for 12-48 hours in the tumor. Thanks to this the tumor/organs ratio achieved 2-150 times for tissue concentration and 2-11 times for fluorescent-contrast by the 6th hour after intravenous injection. Thus, the optimal time for experimental studies of carcinosarcoma photodynamic therapy with laser irradiation was found to be 4-6 days after its transplantation and 6-12 hours after intravenous HpD administration.

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G. D. Litwin, R. D. Barabash, M. I. Petukhov, G. G. Ryansky, V. E. Normansky, K. P. Andreeva, and A. S. Kolobanov "Pharmacokinetics Of Hematoporphyrine Derivative In The Normal And Carcinosarcoma Transplantated Organism", Proc. SPIE 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems, (11 September 1989); https://doi.org/10.1117/12.952049

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