A pilot study of antimicrobial photodynamic therapy of encapsulated Aspergillus fumigatus in a rabbit maxillary sinus model

C. Romo; N. Loebel; D. Meller; R. Andersen

doi:10.1117/12.2526225

7 August 2019 A pilot study of antimicrobial photodynamic therapy of encapsulated Aspergillus fumigatus in a rabbit maxillary sinus model

C. Romo, N. Loebel, D. Meller, R. Andersen

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110708J (2019) https://doi.org/10.1117/12.2526225
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Aspergillus fumigatus is the most common isolated agent in chronic invasive fungal rhinosinusitis with patients enduring painful and recurrent sinus symptoms. Prompt diagnosis and initiation of appropriate therapy is essential to avoid a protracted or fatal outcome. Our group has developed a novel methylene blue-based photodynamic therapy approach to treatment of Aspergillus rhinosinusitis. Briefly, A. fumigatus was encapsulated within 250μm agar beads in a validated model and titrated into the rabbit maxillary sinus. A. fumigatus burden after Sinuwave™ antimicrobial photodynamic therapy was compared to control, with > 99.9% reduction in recoverable fungus, a highly significant outcome.

Citation Download Citation

C. Romo, N. Loebel, D. Meller, and R. Andersen "A pilot study of antimicrobial photodynamic therapy of encapsulated Aspergillus fumigatus in a rabbit maxillary sinus model", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110708J (7 August 2019); https://doi.org/10.1117/12.2526225

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