Learned digital subtraction angiography (Deep DSA): method and application to lower extremities

Elias Eulig; Joscha Maier; Michael Knaup; Thomas Koenig; Klaus Hörndler; Marc Kachelrieß

doi:10.1117/12.2534740

28 May 2019 Learned digital subtraction angiography (Deep DSA): method and application to lower extremities

Elias Eulig, Joscha Maier, Michael Knaup, Thomas Koenig, Klaus Hörndler, Marc Kachelrieß

Proceedings Volume 11072, 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine; 1107223 (2019) https://doi.org/10.1117/12.2534740
Event: Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, 2019, Philadelphia, United States

Abstract

Digital Subtraction Angiography (DSA) aims at selectively displaying vessels by subtracting an unenhanced mask image from a contrast-enhanced fluoroscopic image. This strategy requires the data to be static, i.e. to be acquired without patient or C-arm motion. Thus, conventional DSA cannot be applied to dynamic acquisition protocols such as bolus injection chases, which are particularly useful for the diagnosis of peripheral arterial disease (PAD). Preliminary studies have shown that convolutional neural networks (CNNs) are capable of overcoming this drawback, by predicting DSA-like images directly from their corresponding fluoroscopic x-ray images without the need for the acquisition of a mask image. Here, we demonstrate the potential of this approach for fluoroscopic acquisitions of the lower extremities. We apply the network to twelve different patient exams of which nine are without C-arm motion and the remaining three are bolus chase studies with C-arm motion. For cases where a conventional DSA is feasible we examine very small deviations and observe predictions for the bolus chase studies of similar visual impression as with conventional DSA. The results indicate that Deep DSA has the potential to improve the diagnosis of PAD by generating DSA-equivalent images from bolus chase studies of the lower extremities.

Citation Download Citation

Elias Eulig, Joscha Maier, Michael Knaup, Thomas Koenig, Klaus Hörndler, and Marc Kachelrieß "Learned digital subtraction angiography (Deep DSA): method and application to lower extremities", Proc. SPIE 11072, 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, 1107223 (28 May 2019); https://doi.org/10.1117/12.2534740

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