Visualization and quantification of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime (Conference Presentation)

Julien Bec; Deborah Vela; Jennifer E. Phipps; Michael Agung; Jakob Unger; Ken B. Margulies; Maximilian Buja; Laura Marcu

doi:10.1117/12.2546921

9 March 2020 Visualization and quantification of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime (Conference Presentation)

Julien Bec, Deborah Vela, Jennifer E. Phipps, Michael Agung, Jakob Unger, Ken B. Margulies, Maximilian Buja, Laura Marcu

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Proceedings Volume 11215, Diagnostic and Therapeutic Applications of Light in Cardiology 2020; 112150E (2020) https://doi.org/10.1117/12.2546921
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Fluorescence Lifetime Imaging (FLIm) is a label-free technique that provides biochemical information from biological samples derived from tissue autofluorescence. Using a custom multispectral FLIm/IVUS catheter system, fluorescence lifetime data (n=33,980 locations) was collected from ex vivo human artery segments (n=32 samples). Our findings indicate that intravascular spectroscopy with FLIm supports the identification of early progression-prone lesions, characterized by the accumulation of extracellular lipids, as well as the quantification of inflammatory activity, characterized by macrophage foam cells accumulation. This information improves our understanding of plaque development, which may ultimately be used to improve risk assessment of acute coronary events.

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Julien Bec, Deborah Vela, Jennifer E. Phipps, Michael Agung, Jakob Unger, Ken B. Margulies, Maximilian Buja, and Laura Marcu "Visualization and quantification of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime (Conference Presentation)", Proc. SPIE 11215, Diagnostic and Therapeutic Applications of Light in Cardiology 2020, 112150E (9 March 2020); https://doi.org/10.1117/12.2546921

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KEYWORDS

Luminescence

Microsoft Foundation Class Library

Visualization

Intravascular ultrasound

Arteries

Imaging systems

In vivo imaging

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