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It is very important for the safety of photothermal therapy to detect the temperature change of the interaction between laser and tissue during photothermal therapy. Using photoacoustic imaging can sensitively reflect the temperature distribution in the tissue. This paper proposes a photoacoustic temperature measurement method combined with quantitative absorption distribution. On the one hand, this method uses the temperature measurement method based on photoacoustic imaging to monitor the temperature change of the target area in real time; on the other hand, it quantifies the absorption distribution of the nanoprobe with the photoacoustic and photothermal effect in the target area. Thereby providing a feedback signal for temperature control during the treatment process, realizing precise control of the target area temperature and reconstruction of the absorption distribution of the target area nanoprobe. The study results verify the feasibility of this method. Compared with traditional quantitative methods, this article considers the dynamic changes of the target area temperature and provides treatment feedback. The feedback control guided by multiple parameters minimizes the damage to the surrounding healthy tissues, while improving the accuracy of reconstruction is helpful for the quantitative assessment of the disease.
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