Volumetric measurement of Henle’s fiber layer and outer nuclear layer thickness using directional optical coherence tomography

Shanjida Khan; Shuibin Ni; Thanh-Tin P. Nguyen; Ringo Ng; Brandon J. Lujan; Ou Tan; David Huang; Yifan Jian

doi:10.1117/12.2611598

7 March 2022 Volumetric measurement of Henle’s fiber layer and outer nuclear layer thickness using directional optical coherence tomography

Shanjida Khan, Shuibin Ni, Thanh-Tin P. Nguyen, Ringo Ng, Brandon J. Lujan, Ou Tan, David Huang, Yifan Jian

Author Affiliations +

Proceedings Volume 11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; 1194802 (2022) https://doi.org/10.1117/12.2611598
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Thinning of the outer nuclear layer (ONL) is an important pathological feature and possible biomarker of age-related macular degeneration (AMD). The demarcation of the ONL and Henle’s fiber layer (HFL) is visually unattainable with standard optical coherence tomography (OCT) imaging. In this work, we built a volumetric directional OCT prototype which constitutes two optical scanners in the sample arm that synchronously scan the imaging beam on the pupil and retina. The imaging beam’s entry positions and incident angles on the pupil and retina respectively are precisely controlled and optimally maintained to generate sufficient contrast of the HFL over the entire macular volume.

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Shanjida Khan, Shuibin Ni, Thanh-Tin P. Nguyen, Ringo Ng, Brandon J. Lujan, Ou Tan, David Huang, and Yifan Jian "Volumetric measurement of Henle’s fiber layer and outer nuclear layer thickness using directional optical coherence tomography", Proc. SPIE 11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, 1194802 (7 March 2022); https://doi.org/10.1117/12.2611598

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