LLNL Center for Microtechnology: capabilities, customers, case study -- HANAA (Handheld Nucleic Acid Analyzer)

Raymond P. Mariella Jr.

doi:10.1117/12.500360

18 June 2003 LLNL Center for Microtechnology: capabilities, customers, case study -- HANAA (Handheld Nucleic Acid Analyzer)

Raymond P. Mariella Jr.

Author Affiliations +

Proceedings Volume 5001, Optical Engineering at the Lawrence Livermore National Laboratory; (2003) https://doi.org/10.1117/12.500360
Event: High-Power Lasers and Applications, 2003, San Jose, CA, United States

Abstract

The polymerase chain reaction (PCR) is an enzyme-based chemical reaction that manufactures copies of one or more identifying regions of double-stranded DNA sequences (target sequences). These copies of target DNA are known as "amplicons". By creating millions of these copies of the identifying sequences (when they are present!), PCR allows researchers to detect by them, and hence the presence of the relevant organism, with techniques such as electrophoresis, flow cytometry, or spectrometry. Although there are numerous commercial PCR instruments that are designed for bench-top use in a laboratory, the challenges of building a battery-powered instrument that could perform such assays in the field.

Citation Download Citation

Raymond P. Mariella Jr. "LLNL Center for Microtechnology: capabilities, customers, case study -- HANAA (Handheld Nucleic Acid Analyzer)", Proc. SPIE 5001, Optical Engineering at the Lawrence Livermore National Laboratory, (18 June 2003); https://doi.org/10.1117/12.500360

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