Extraction of tissue optical properties from optical coherence tomography images for diagnostic purposes

Lars Thrane; Michael H. Frosz; David Levitz; Thomas M. Jorgensen; Claus B. Andersen; Peter R. Hansen; Jurga Valanciunaite; Johannes Swartling; Stefan Andersson-Engels; Andreas Tycho; Harold T. Yura; Peter E. Andersen

doi:10.1117/12.634767

22 June 2005 Extraction of tissue optical properties from optical coherence tomography images for diagnostic purposes (Invited Paper)

Lars Thrane, Michael H. Frosz, David Levitz, Thomas M. Jorgensen, Claus B. Andersen, Peter R. Hansen, Jurga Valanciunaite, Johannes Swartling, Stefan Andersson-Engels, Andreas Tycho, Harold T. Yura, Peter E. Andersen

Author Affiliations +

Proceedings Volume 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI; (2005) https://doi.org/10.1117/12.634767
Event: Saratov, Russia, 2004, Saratov, Russian Federation

Abstract

The concept of optical coherence tomography (OCT) for high-resolution imaging of tissues in vivo is introduced. Analytical and numerical models for describing and understanding the light propagation in samples imaged by OCT systems are presented. An analytical model for calculating the OCT signal based on the extended Huygens-Fresnel principle and valid both for single and multiple scattering regimes is outlined. From this model, an algorithm for extracting tissue optical properties for multi-layered tissues is derived. The algorithm is first verified for various optical properties and geometries using solid phantoms and numerical simulations. The applicability of the algorithm for extraction of tissue optical properties is then demonstrated for vascular tissue samples ex vivo. With the use of data from numerical phantoms, the validity of the OCT extraction algorithm for a two-layer geometry is further supported. It is concluded that by using optical properties extracted from OCT images of human tissues, the clinical utility of OCT imaging can be substantially increased.

Citation Download Citation

Lars Thrane, Michael H. Frosz, David Levitz, Thomas M. Jorgensen, Claus B. Andersen, Peter R. Hansen, Jurga Valanciunaite, Johannes Swartling, Stefan Andersson-Engels, Andreas Tycho, Harold T. Yura, and Peter E. Andersen "Extraction of tissue optical properties from optical coherence tomography images for diagnostic purposes (Invited Paper)", Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); https://doi.org/10.1117/12.634767

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available