A study on the spectral dependence of second harmonic generation from collagen tissues

Mengzhe Shen; Hequn Wang; Anthony Lee; Jianhua Zhao; Haishan Zeng; Shuo Tang

doi:10.1117/12.909646

9 February 2012 A study on the spectral dependence of second harmonic generation from collagen tissues

Mengzhe Shen, Hequn Wang, Anthony Lee, Jianhua Zhao, Haishan Zeng, Shuo Tang

Proceedings Volume 8226, Multiphoton Microscopy in the Biomedical Sciences XII; 82263R (2012) https://doi.org/10.1117/12.909646
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

The spectral dependence of SHG intensity in biological tissues is an optical property that is not fully understood so far. In this paper, we will investigate this problem in detail through experiments. Through examining different biology tissues, it is found that SHG intensity drops down from shorter to longer wavelength from 375 nm to 460 nm. By comparing these curves with 1/λn dependence, the n is found to vary from 4.5 to 8.5. These patterns can not be fully explained by scattering properties of collagen. Other factors such as direct generation of SHG may have contribution to these wavelength dependence patterns, which needs further investigation.

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Mengzhe Shen, Hequn Wang, Anthony Lee, Jianhua Zhao, Haishan Zeng, and Shuo Tang "A study on the spectral dependence of second harmonic generation from collagen tissues", Proc. SPIE 8226, Multiphoton Microscopy in the Biomedical Sciences XII, 82263R (9 February 2012); https://doi.org/10.1117/12.909646

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KEYWORDS

Second-harmonic generation

Collagen

Photons

Tissues

Rayleigh scattering

Scattering

Mie scattering

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