Antimicrobial blue light for prevention of lethal Vibrio vulnificus infection in mice

Carolina dos Anjos; Leon G. Leanse; Richard R. Anderson; Tianhong Dai

doi:10.1117/12.2610455

7 March 2022 Antimicrobial blue light for prevention of lethal Vibrio vulnificus infection in mice

Carolina dos Anjos, Leon G. Leanse, Richard R. Anderson, Tianhong Dai

Proceedings Volume PC11939, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2022; PC1193908 (2022) https://doi.org/10.1117/12.2610455
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

In this study, we first evaluated the effectiveness of antimicrobial blue light (aBL) in vitro against Vibrio vulnificus in planktonic and biofilm cultures. In addition, we assessed aBL for the prevention of potentially lethal burn infections caused by Vibrio vulnificus in mice. We found that aBL was highly effective in killing V. vulnificus in both planktonic and biofilm cultures. Moreover, aBL significantly reduced the bacterial burden in infected mouse burns and reduced the rate of fatal sepsis in mice.

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Citation Download Citation

Carolina dos Anjos, Leon G. Leanse, Richard R. Anderson, and Tianhong Dai "Antimicrobial blue light for prevention of lethal Vibrio vulnificus infection in mice", Proc. SPIE PC11939, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2022, PC1193908 (7 March 2022); https://doi.org/10.1117/12.2610455

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