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16 March 2023 Volumetric differential contrast imaging by computationally augmented optical coherence tomography microscopy (Conference Presentation)
Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtengger, Junya Tamaoki, Lixuan Bian, Makoto Kobayashi, Tomoko Mori, Satoshi Matsusaka, Yoshiaki Yasuno
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Proceedings Volume PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; PC1239111 (2023) https://doi.org/10.1117/12.2648746
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
We introduce volumetric differential contrast (VDC) imaging using optical coherence tomography (OCT). This method was designed based on a new theoretical model of OCT, the disperse scatterer model (DSM). VDC gives the differential image of “the product of the refractive index distribution and the scatterer density” through complex numerical processing of OCT signals. The method was validated by in-vitro and in-vivo samples measured by spectral domain OCT. Differential contrast images with arbitrary shear amount and shear direction were obtained at arbitrary depth positions by a single measurement by numerically applying defocus by holographic signal processing after the signal acquisition.
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Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtengger, Junya Tamaoki, Lixuan Bian, Makoto Kobayashi, Tomoko Mori, Satoshi Matsusaka, and Yoshiaki Yasuno "Volumetric differential contrast imaging by computationally augmented optical coherence tomography microscopy (Conference Presentation)", Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC1239111 (16 March 2023); https://doi.org/10.1117/12.2648746
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KEYWORDS
Optical coherence tomography
Microscopy
Optical microscopy
3D modeling
Digital image correlation
Refractive index
Signal processing
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