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13 March 2024 Verteporfin photodynamic therapy enhances therapeutic delivery of a tumor suppressor microRNA to pancreatic cancer cells
Vida Karimnia, Shakir Khan, Frank Slack, Jonathan P. Celli
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Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC128230G (2024) https://doi.org/10.1117/12.3004781
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Countless trials of chemotherapy and/or targeted agent combinations have failed to produce substantial gains in survival for patients with pancreatic ductal adenocarcinoma. Recent studies have demonstrated exciting potential of RNA medicine approaches to therapeutically target microRNAs (miRNA, small non-coding RNAs) either by inhibiting tumor promoting miRNAs (onco-miRs) or enriching tumor suppressor miRNAs. Here we use co-culture and murine models to show that photodynamic therapy (PDT) using verteporfin both improves delivery and synergizes mechanistically with tumor suppressive effects of miR-146a-5p. These results indicate promise RNA medicine strategies for PDAC and could have broader applicability in therapeutic delivery of RNA medicine to solid tumors.
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Vida Karimnia, Shakir Khan, Frank Slack, and Jonathan P. Celli "Verteporfin photodynamic therapy enhances therapeutic delivery of a tumor suppressor microRNA to pancreatic cancer cells", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC128230G (13 March 2024); https://doi.org/10.1117/12.3004781
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KEYWORDS
Photodynamic therapy
Tumors
Medicine
Pancreatic cancer
3D modeling
Nanoparticles
3D acquisition
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