Functional imaging of trabecular meshwork using phase-sensitive optical coherence tomography

Zhaoyu Gong; Murray A. Johnstone; Ruikang K. Wang

doi:10.1117/12.3005729

13 March 2024 Functional imaging of trabecular meshwork using phase-sensitive optical coherence tomography

Zhaoyu Gong, Murray A. Johnstone, Ruikang K. Wang

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC128240T (2024) https://doi.org/10.1117/12.3005729
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Glaucoma research benefits from studying the trabecular meshwork (TM) and associated biomarkers, which is facilitated by the functional imaging of the TM motion using optical coherence tomography (OCT). Current TM measurement methods require an external cardiac pulse recording device, adding cost and complexity. Our study replaces external pulse monitoring with anterior ciliary artery (ACA) flow velocity monitoring. We implement MB mode on OCT, where the intra M-scan phase difference is to assess the ACA flow velocity, while the inter B-scan phase difference is to quantify TM motion. This cost-effective approach was successfully demonstrated on a human subject and can be readily integrated into existing clinical OCT systems, enhancing glaucoma exploration and diagnosis.

Conference Presentation

Citation Download Citation

Zhaoyu Gong, Murray A. Johnstone, and Ruikang K. Wang "Functional imaging of trabecular meshwork using phase-sensitive optical coherence tomography ", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC128240T (13 March 2024); https://doi.org/10.1117/12.3005729

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