Near-infrared irradiation in translational research over brain dysfunction treatment

Sergei G. Sokolovski; Edik Rafailov

doi:10.1117/12.3013463

13 March 2024 Near-infrared irradiation in translational research over brain dysfunction treatment

Sergei G. Sokolovski, Edik Rafailov

Proceedings Volume PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI; PC128410K (2024) https://doi.org/10.1117/12.3013463
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The progress in laser-based technologies helps to implement compact and reliable semiconductor light sources emitting in near-infrared (NIR) spectrum range significantly gaining PBM effect deeper in the brain. Here we focus on applications of the NIR laser of 1267 nm, proving its efficiency in transforming 3O2 to its active form of 1O2 in anoxygenic organic solution. Later it was demonstrated that a shift in redox potential triggered by NIR laser in different cell types including primary neurons and astrocytes where activation of ATP synthesis was detected. And finally a 4-week course of photosenitiser-free NIR laser treatment (LT), non-invasively suppresses the glioblastoma (GBM) growth in rats and significantly increases animal survival rate. The animals with GBM LT suppressed the GBM progression through activation of apoptosis of the GBM cells and inhibition of their proliferation. Therefore, the PS-free-LT may become a promising alternative therapeutic approach in developing a breakthrough technology for the non-invasive treatment of GBM.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Sergei G. Sokolovski and Edik Rafailov "Near-infrared irradiation in translational research over brain dysfunction treatment", Proc. SPIE PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI, PC128410K (13 March 2024); https://doi.org/10.1117/12.3013463

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