Prof. Evelyn Gaffal Profile

Prof. Evelyn Gaffal

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 6 March 2023 Presentation + Paper

Multimodal imaging system with ultrasound, photoacoustics, and optical coherence tomography for optical biopsy of melanoma

Anatoly Fedorov Kukk, Di Wu, Evelyn Gaffal, Rüdiger Panzer, Steffen Emmert, Bernhard Roth

Proceedings Volume 12371, 1237107 (2023) https://doi.org/10.1117/12.2648257

KEYWORDS: Optical coherence tomography, Skin, Melanoma, Ultrasonography, Skin cancer, Raman spectroscopy, Multimodal imaging, Photoacoustic tomography, Ultrasound tomography, 3D imaging metrology

Read Abstract +

The rate of skin cancer incidence including melanoma has been steadily increasing in the last decades. While melanoma often show little to no symptoms in the early stages, they can spread to the lymph nodes and drastically reduce survival chances in the later stages. The current gold standard for diagnosis is visual examination, excision, and histological examination of the sample tissue, which is an invasive, costly and time-consuming process. As an alternative to this procedure, we introduce a novel multimodal optical system that integrates ultrasound (US), photoacoustic tomography (PAT), and optical coherence tomography (OCT) with Raman spectroscopy (RS). The setup allows quick and non-invasive skin lesion diagnosis and the determination of 3D lesion depth, helping the dermatologists make a decision on the excision margins. The OCT delivers structural and depth information of thin skin lesions, while the US and PAT measure the penetration depth of thicker lesions and the RS analyzes the chemical composition that can be used to distinguish between benign and malignant skin lesions. In our setup, the RS and OCT share the optical path and the scanning elements, which allows colocalized measurements. The US and PAT are integrated with an acoustical reflector, which enables B-mode measurements at the same position as OCT and RS without switching the scanning head. We demonstrate the imaging capabilities of the multimodal setup on custom made agar phantoms and present first measurements on ex vivo mouse and in vivo human skin samples. We compare the results with the corresponding histological images.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years