Significance: The light dose in photodynamic therapy (PDT) has a considerable influence on its treatment effect, and irradiance uniformity is an issue of much concern for researchers. However, achieving intelligent and personalized dosimetry adjustments remains a challenge for current PDT instruments.
Aim: To meet the requirements of intelligent and personalized dosimetry adjustments for the light dose on an irregular surface, a new PDT device with its optimal control method is proposed.
Approach: This research introduces a new PDT device that includes a 3D scanner, a light-emitting diode (LED) array, and a computer. The 3D scanner is proposed to generate the point cloud of the lesion and the LED array light source, and obtain the relative position and rotation parameters between them. Then, an image segmentation algorithm is used to segment the lesion point cloud into several cluster regions. Last, the current of each LED unit is adjusted separately to achieve the expected irradiance on each cluster.
Results: Compared with the general light source, the optimized light source increases the effective irradiance area by 9% to 15% and improves its uniformity by ∼9 % on a human port-wine stain head model.
Conclusions: The device and its optimal method may be used for optimizing the light dosimetry to realize intelligent and personalized treatment.
Vascular targeted photodynamic therapy (VPDT) is a new targeted therapy that relies on light as a precise spatially and temporally stimulus. An improved understanding of the interaction between photosensitizers, oxygen and light elements is of great significance to improve the outcomes. A VPDT device for animal evaluation is designed to meet the needs on the regulation of light distribution and irradiance on a same sample. The device is composed of a programmable light source and a micro-camera. The irradiance and spatial distribution can be adjusted by the light-emitting diode current and the duty cycle of the digital micromirror. Experiments show that the optical uniformity of the device is better than 96 percent, the dynamic range is up 28,815 to 1, and the position resolution is 7.6 micron, which can be used for animal experiment.
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