Hypericin (Hyp) has received attention due to its high phototoxicity against viruses and anti-tumor photoactivity. Using
two-photon imaging, we demonstrated that Hyp induced photosensitized modification of collagen fibers in native tissues.
Dynamics of photo-processes was monitored by time-lapse multiphoton imaging. We showed that Hyp–mediated
processes in collagen tissues may be used for the selective modification of collagen fibers.
V. Hovhannisyan, A. Hovhannisyan, V. Ghukasyan, H. W. Guo, Hung-Ming Lin, S. J. Chen, Yang-Fang Chen, and Chen-Yuan Dong, "Hypericin-mediated selective photomodification of connective tissues," Proc. SPIE 10037, Photonics in Dermatology and Plastic Surgery, 100370O (Presented at SPIE BiOS: January 29, 2017; Published: 13 February 2017); https://doi.org/10.1117/12.2255028.
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