Amyloidosis is an unknown pathogenic process in which abnormally folded proteins are deposited in the extracellular space as macroscopic aggregates. Laryngeal deposits of these proteins are extremely rare, but primarily cause dysphonia in patients. High Speed Digital Phonoscopy (HSDP) was used to capture the kinematics of vocal folds in a patient with laryngeal amyloidosis. Acoustic data was also recorded and both HSDP and acoustics were processed using custom Vocalizer® software to help elucidate the physiological impact of amyloids in the larynx, especially in regards to effects on the voice.
Matthew Blanco, Raul M. Cruz, Krzysztof Izdebski, and Yuling Yan, "Analysis of laryngeal amyloidosis using high speed digital phonoscopy and acoustics (Conference Presentation)," Proc. SPIE 10039, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology, 100390B (Presented at SPIE BiOS: January 28, 2017; Published: 19 April 2017); https://doi.org/10.1117/12.2256706.5369914026001.
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