Preterm birth (PTB) presents a serious medical heath concern in both economically developed
and developing nations, with incidence rate from 15%-11% respectively. Changes in cervical
collagen bundle orientation and distribution may prove to be a predictor of PTB. Polarization
imaging is an effective means to measure optical anisotropy in birefringent biological tissue such
as those rich in collagen. Non-invasive, full-field Mueller Matrix polarimetry (MMP) imaging
methodologies, optical coherence tomography (OCT), and second harmonic generation (SHG)
microscopy were used to assess cervical collagen content and structure in non-pregnant cervices.
In vivo studies using a Mueller Matrix colposcope are underway. Further studies of cervical
collagen orientation throughout pregnancy are needed to understand if Mueller matrix
polarimetry can effectively identify at-risk conditions for PTB.
Karla A. Montejo, Joseph Chue-Sang, Yuqiang Bai, Susan Stoff, Nola Holness, Mariacarla Gonzalez, Jefferson Gomes, Amir Gandjbakhche, Viktor V. Chernomordik, and Jessica C. Ramella-Roman, "Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy," Proc. SPIE 10043, Diagnosis and Treatment of Diseases in the Breast and Reproductive System, 1004303 (Presented at SPIE BiOS: January 28, 2017; Published: 2 March 2017); https://doi.org/10.1117/12.2250987.
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