We will present our results of evaluating the feasibility of using the mouse eye as a window for non-invasive, long-term, optical investigation of xenograft models, using multimodal, cellular-resolution ocular imaging. As an “approachable part of the brain”, the retina allows examination of such issues as drug delivery across the blood retinal barrier (BRB) and blood brain barrier (BBB). Our custom-built wide-field SLO/OCT provided repeatable in vivo imaging over many weeks, allowing quantitative tracking of tumor growth, the delivery of theranostic nanoparticles, and the measurement of tumor microenvironment responses. Additionally, we were able to specifically control the spatial extent of light activated photodynamic therapy (PDT) and photothermal therapy (PTT) via efficient free radical and heat generation at the tumor site, respectively.
Mayank Goswami, Xinlei Wang, Pengfei Zhang, Wenwu Xiao, Kit S. Lam, Edward N. Pugh, and Robert J. Zawadzki, "Methods for non-surgical cancer nano-theranostics of ocular tumors in the mouse eye (Conference Presentation)," Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100450C (Presented at SPIE BiOS: January 28, 2017; Published: 16 May 2017); https://doi.org/10.1117/12.2251803.5370275043001.
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