Glaucoma is a group of eye diseases which results in optic nerve damage and vision loss. Optical coherence tomography (OCT) has been widely used to investigate geometric risk factor of glaucoma. However, material properties of ONH are also important to understand intra-ocular pressure related stress. We developed Jones-matrix based multifunctional posterior eye OCT (JM-OCT), which uses 1-μm band swept-source with a 100-kHz A-line rate. It provides three different optical properties, attenuation coefficient (AC), local birefringence (LB), and optical coherence angiography (OCA). We investigated the utility those properties for the investigation of normal ONH cases. 3 mm x 3 mm area around ONH was scanned for each eye, and biometric parameters were measured in hospital. Statistical analyses were performed with the mean values of above parameters at the regions of prelamina, lamina cribrosa, peripapillary sclera, and peripapillary nerve fiber layer, and biometric parameters of age, axial eye length, refractive error, and intraocular pressure. In qualitative observation, the lamina cribrosa generally shows more hyper signals in AC, LB, and OCA than prelamina. In t-test, AC, LB, and OCA showed significant difference (p < 0.05) between prelamina and lamina cribrosa, while conventional OCT did not. In correlation test, axial eye length is positively correlated with LB and AC in lamina cribrosa. And these LB and AC are also negatively correlated with the refractive error. Age was found to be negatively correlated with OCA in lamina cribrosa.
Young-Joo Hong, Aaron C. Chan, Deepa K. Kasaragod, Shuichi Makita, Masahiro Miura, and Yoshiaki Yasuno, "Investigation of multiple optical and biometric properties of optic nerve head (Conference Presentation)," Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100450S (Presented at SPIE BiOS: January 29, 2017; Published: 16 May 2017); https://doi.org/10.1117/12.2250803.5370275055001.
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