To investigate the application of wide field OCT angiography (OCTA) in living human eye. Normal and pathologic eyes
were recruited and imaged by a 1060 nm swept source OCTA system with A-line speed of 100 kHz provided by Carl
Zeiss Meditec. Inc.. Wide field OCTA images were generated in a single scan within 5 seconds based on the tracking
capability installed in the system with 9 x 9 mm2 and 12 x 12 mm2 field of view and sampled by 500 A-lines x 500 Bframes
with 2 repetitions in the same location for one 3D data. Complex optical microangiography (OMAG) algorithm
was used to extract the blood flow information. The en face maximum projection provided by the device was used to
generate 2-dimensional angiograms of different layers and color-code images. Wide field en face OCTA images of
different macular diseases showed a great agreement with fluorescein angiography (FA). Meanwhile, OCTA provides
depth-resolved information and detailed vascular images of venous occlusion and DR patients in far peripheral region,
and choroidal vessels imaging in serpiginous choroidopathy patient, providing a better visualization of vascular network
compared to FA.
Qinqin Zhang, Chieh-Li Chen, Zhongdi Chu, and Ruikang K. Wang, "Wide field OCT angiography by using swept source OCT in living human eye," Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100450V (Presented at SPIE BiOS: January 29, 2017; Published: 8 February 2017); https://doi.org/10.1117/12.2251029.
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