Age-related changes in the crystalline lens shape and refractive index gradient produce changes in dioptric power and high-order aberrations that influence the optics of the whole eye and contribute to a decrease in overall visual quality. Despite their key role, the changes in lens shape and refractive index gradient with age and accommodation and their effects on high-order aberrations are still not well understood. The goal of this project was to develop a combined laser ray tracing (LRT) and optical coherence tomography (OCT) system to measure high-order aberrations, shape and refractive index gradient in non-human primate and human lenses. A miniature motorized lens stretching system was built to enable imaging and aberrometry of the lens during simulated accommodation. A positioning system was also built to enable on- and off-axis OCT imaging and aberrometry for characterization of the peripheral defocus of the lens. We demonstrated the capability of the LRT-OCT system to produce OCT images and aberration measurements of crystalline lens with age and accommodation in vitro. In future work, the information acquired with the LRT-OCT system will be used to develop an accurate age-dependent lens model to predict the role of the lens in the development of refractive error and aberrations of the whole eye.
Marco Ruggeri, Bianca M. Maceo Heilman, Yue Yao, Yu-Cherng Chang, Alex Gonzalez, Cornelis Rowaan, Ashik Mohamed, Siobhan Williams, Heather A. Durkee, Juan Silgado, Andres Bernal, Esdras Arrieta-Quintero, Arthur Ho, Jean-Marie A. Parel, and Fabrice Manns, "Combined laser-ray tracing and OCT system for biometry of the crystalline lens (Conference Presentation)," Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100451F (Presented at SPIE BiOS: January 29, 2017; Published: 16 May 2017); https://doi.org/10.1117/12.2256235.5370275067001.
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