Many biologically active molecules are chiral. Many drugs, which are currently in use, are supplied as an equimolar
mixture of enantiomers. Although they have the same chemical structure, i.e. are not distinguishable by conventional
Raman spectroscopy, most isomers of chiral drugs exhibit marked differences in biological activities such as
pharmacology, toxicology, pharmacokinetics, metabolism, etc. In this report we introduced a new spectroscopic tool to
extend nonlinear Raman spectroscopy to chiral substances.
Georgi I. Petrov and Vladislav V. Yakovlev, "Towards noninvasive drug distribution in tissues: coherent Raman microspectroscopy of chiral molecules," Proc. SPIE 10046, Visualizing and Quantifying Drug Distribution in Tissue, 1004604 (Presented at SPIE BiOS: January 28, 2017; Published: 21 February 2017); https://doi.org/10.1117/12.2252944.
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