Uniform delivery of light fluence is an important goal for photodynamic therapy. We present summary results for an
infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of
the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the
current intrapleural PDT protocol, 8 detectors placed in selected locations in the pleural cavity monitor the light doses.
To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as
well as the surface contour of the pleural cavity. A MATLAB-based GUI program is developed to display the light dose
in real-time during PDT to guide the PDT treatment delivery to improve the uniformity of the light dose. A dualcorrection
algorithm is used to improve the agreement between calculations and in-situ measurements. A
comprehensive analysis of the distribution of light fluence during PDT is presented in both phantom conditions and in
Timothy C. Zhu, Michele M. Kim, Yi-Hong Ong, Rozhin Penjweini, Andreea Dimofte, Jarod C. Finlay, Carmen Rodriguez, and Keith A. Cengel, "A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT," Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 1004709 (Presented at SPIE BiOS: January 28, 2017; Published: 21 February 2017); https://doi.org/10.1117/12.2253027.
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