The paper first reviews the main laser based cancer therapies and then presents a new 9xx nm high power laser diode system specifically devised to irradiate carbon graphitic nanoparticles that have shown photodynamic and photo-thermal behavior when exposed to near-IR laser light. The peculiarity of the laser system is that its delivery is through a fiber probe that integrates Bragg gratings to allow monitoring the induced temperature increase without introducing artifacts due to the interaction with the laser beam. Experimental validations through EPR spectrum and temperature measurements on hydroxylated fullerene and carbon nanoparticle samples are provided to assess the effectiveness of the developed system.
Riccardo Gassino, Ida Kokalari, Alberto Vallan, Ivana Fenoglio, and Guido Perrone, "A compact diode laser based all-fiber delivery system for PDT+PTT with integrated temperature sensing capabilities," Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 100470G (Presented at SPIE BiOS: January 29, 2017; Published: 8 February 2017); https://doi.org/10.1117/12.2254796.
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