The main goal of the study was a vasculature targeted PDT. A new approach named M-mode-like OCT (MML OCT)
was applied to monitor early response to PDT. Due to the chosen filtering parameters (96 Hz filter threshold), this
approach visualizes only vessels with flowing blood. Without flowing blood even filled vessels are not visualized
because flow-less blood causes speckle variations with significantly lower frequencies (<50 Hz corresponding to speckle
decorrelation time for stationary blood). This feature allows us to detect thrombosis of blood vessels, the results of MML
OCT and histological examination being perfectly coinciding. The advantages of MML OCT such as a simple and fast
process of obtaining microvasculature images and label-free nature of the visualization makes this method perspective in
routine clinical monitoring of antitumor therapies.
Marina A. Sirotkina, Ekaterina V. Gubarkova, Elena B. Kiseleva, Vladimir Y. Zaitsev, Mikhail Y. Kirillin, Alexander A. Sovetsky, Alexander L. Matveyev, Lev A. Matveev, Sergey S. Kuznetsov, Elena V. Zagaynova, Alex Vitkin, and Natalia D. Gladkova, "Multimodal OCT for assessment of vasculature-targeted PDT success," Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 100470Q (Presented at SPIE BiOS: January 29, 2017; Published: 8 February 2017); https://doi.org/10.1117/12.2251914.
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Monte Carlo based light propagation models to improve efficacy of biophotonics based therapeutics of hollow organs and solid tumours including photodynamic therapy and photobiomodulation (Conference Presentation)