Effective photodynamic therapy (PDT) treatment planning and treatment monitoring requires computer simulations of
both light transport in tissue and photosensitizer (PS) photophysics to accurately estimate singlet oxygen. Simply using
fixed prescribed values of light dose (fluence) or PDT dose (the time integral of ‘PS concentration’ times the ‘fluence
rate’) – one value for all patients – does not account for differences in the amount of singlet oxygen formed when
fluence rates change or patient tissue parameters change. We will focus on singlet oxygen dose which is calculated by
solving the photokinetics rate equations and which determines the effectiveness of the subsequent reactions of singlet
oxygen with the cancer target and the negative effect of PS photobleaching.
Karl Beeson, Evgueni Parilov, and Mary Potasek, "Overview of computational simulations for PDT treatments based on optimal choice of singlet oxygen," Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 100470R (Presented at SPIE BiOS: January 29, 2017; Published: 8 February 2017); https://doi.org/10.1117/12.2252552.
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