Photobiomodulation with low-power, high-fluence light in the near-infrared range (600-1100nm), also known as low
level laser therapy (LLLT), has been used for promoting healing of wounds, reducing pain, and so on. Understanding its
physiological effect is essential for treatment optimization and evaluation. In this study, we used diffuse correlation
spectroscopy (DCS) to investigate the changes of regional blood flow in skeletal muscle induced by a single session of
LLLT. DCS is an emerging optical modality to probe microvascular blood flow in human tissues in vivo. We have
developed a software-based autocorrelator system with the benefits such as flexibility in raw photon count data
processing, portability and low cost. LLLT was administered at the human forearm with a 1064-nm, continuous-wave
laser. The emitting power was 3.4 W in an area of 13.6 cm2, corresponding to 0.25W/cm2 irradiance. The emitting
duration was 10 minutes. Eight healthy adults of any ethnic background, in an age range of 18-40 years old were
included. The results indicate that LLLT causes reliable changes in regional blood flow. However, it remains unclear
whether these changes are physiological or attributed to the heating effect of the stimulation laser.
Sagar Soni, Xinlong Wang, Hanli Liu, and Fenghua Tian, "Diffuse correlation spectroscopy (DCS) study of blood flow changes during low level laser therapy (LLLT): a preliminary report," Proc. SPIE 10048, Mechanisms of Photobiomodulation Therapy XII, 1004806 (Presented at SPIE BiOS: January 28, 2017; Published: 17 February 2017); https://doi.org/10.1117/12.2252604.
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