Plasmon resonance associated with nanoparticles of gold can enable photothermal ablation of tissues or controlled drug
release with exquisite temporal and spatial control. These technologies may support many applications of precision
medicine. However, clinical implementations of these technologies will require new methods of intraoperative imaging
and guidance. Near-infrared laser surgery is a prime example that relies on improved image guidance. Here we set forth
applications of augmented microscopy in guiding surgical procedures employing plasmon resonant gold-coated
liposomes. Absorption of near-infrared laser light is the first step in activation of various diagnostic and therapeutic
functions of these novel functional nanoparticles. Therefore, we demonstrate examples of near-infrared visualization of
the laser beam and gold-coated liposomes. The augmented microscope proves to be a promising image guidance platform
for a range of image-guided medical procedures.
Jeffrey R. Watson, Summer Garland, and Marek Romanowski, "Intraoperative visualization of plasmon resonant liposomes using augmented microscopy," Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 100490L (Presented at SPIE BiOS: January 29, 2017; Published: 8 February 2017); https://doi.org/10.1117/12.2248706.
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