Fluorescence imaging is a novel intraoperative technique for guiding oncologic surgeons toward radical tumor
resections. Application of various fluorescent agents in exploratory clinical trials has already yielded promising results.
The field of fluorescence imaging must now move beyond the proof-of-concept phase toward clinical application and
implementation. This shift encompasses several hurdles, including standardization, advanced-phase study endpoints,
regulatory affairs and routine implementation, which need to be addressed by the community in close collaboration with
all stakeholders. These challenges, and the possible actions to overcome them and promote and accelerate clinical
implementation of fluorescence imaging, are summarized in this paper.
Charlotte E. S. Hoogstins, Henricus J. M. Handgraaf, Leonora S. F. Boogerd, Jacobus Burggraaf, and Alexander L. Vahrmeijer, "Image guided surgery using near-infrared fluorescence: road to clinical translation of novel probes for real time tumor visualization," Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 100490X (Presented at SPIE BiOS: January 29, 2017; Published: 8 February 2017); https://doi.org/10.1117/12.2260520.
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Study of self-shadowing effect as a simple means to realize nanostructured thin films and layers with special attentions to birefringent obliquely deposited thin films and photo-luminescent porous silicon