A tomographic reconstruction algorithm for Cherenkov-excited luminescence scanned imaging (CELSI) is proposed and
demonstrated for the first time, to reconstruct distributions of luminescent source. Coupled continuous wave (CW)
diffusion equations are used to model luminescent photon propagation in biological tissues. The CELSI reconstruction
was achieved by minimizing the difference between measured and computed data based on Tikhonov regularization
technique. The feasibility and effectiveness of the algorithm were tested with numerical simulations on noisy data. In
addition, comparisons between conventional diffuse optical fluorescence tomography (DOFT) and CELSI were also
performed. Contrast-detail analysis was also used to evaluate the imaging performance of CELSI.
Jinchao Feng, Petr Bruza, Hamid Dehghani, Scott C. Davis, and Brian W. Pogue, "Cherenkov-excited luminescence sheet imaging (CELSI) tomographic reconstruction," Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 1004912 (Presented at SPIE BiOS: January 30, 2017; Published: 8 February 2017); https://doi.org/10.1117/12.2250670.
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