Optical and ionizing radiation are two physical ways in which we can probe the living world. Until recently, these forms
of radiation were used in distinct imaging and therapeutic applications—radiation therapy, photodynamic therapy, X-ray
imaging, and diffuse optical tomography, to name a few. It has now been recognized that physical phenomena in which
ionizing radiation and light are inherently coupled may provide powerful new capabilities for imaging and treating
diseases. This presentation will review the physics and applications of radioluminescence, with a particular focus on
molecular imaging. One such method, X-ray luminescence computed tomography (XLCT), uses narrow kilovolt X-ray
beams to stimulate optical emissions from biologically targeted radioluminescent nanoparticles, thus providing high-resolution
images even deep in tissue. A different phenomenon, Cherenkov luminescence, can also be harnessed to
localize radiopharmaceuticals in vivo, allowing surgeons to visualize the molecular status of the tissues they are
resecting. Recent progress towards routine implantation of these methods will be reviewed and sources of endogenous
radioluminescence signal will be discussed.
Guillem Pratx, "A tale of two photons: radioluminescence and its application in molecular imaging," Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 1004916 (Presented at SPIE BiOS: January 30, 2017; Published: 8 February 2017); https://doi.org/10.1117/12.2256702.
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