Accurate and efficient reconstruction of hemodynamic changes is an important step towards the implementation of NIRS as an enhanced clinical tool for understanding oxygenation changes at various depths within the brain. Depth information could provide insight on how oxygen transported to the tissue. For this work, we ran Monte Carlo simulations to develop sensitivity profiles for various source-detector separations. The source-detector separations were based on our custom built 108 channel NIRS probe and consisted of separations of 15 mm, 30 mm, 36 mm, and 45 mm. We used the mesh-based Monte Carlo program MMCLAB (Fang et al. 2010) to acquire the sensitivity profiles. The sensitivity profiles consisted of a tetrahedral mesh which was converted to a regular grid in three-dimensional space. Then, the structural tensor was calculated for each voxel and the Hamilton-Jacobi equation was solved anisotropically for the tensor volume. As the result, the distance map was in same space as the calculated tensor volume. Using this distance map, we modeled the probabilistic path of photons. We then weighted the hemodynamic changes acquired by our NIRS probe according to the probabilistic path to reconstruct hemodynamic changes in the prefrontal area of the brain.
Zephaniah Phillips, Sung-Woo Kim, Seung-Ho Paik, Youngwoon Choi, Joon-Kyung Seong, and Beop-Min Kim, "Real time imaging kernel based on Monte Carlo-determined photon paths (Conference Presentation)," Proc. SPIE 10051, Neural Imaging and Sensing, 1005111 (Presented at SPIE BiOS: February 01, 2017; Published: 19 April 2017); https://doi.org/10.1117/12.2251693.5371358610001.
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Monte Carlo based light propagation models to improve efficacy of biophotonics based therapeutics of hollow organs and solid tumours including photodynamic therapy and photobiomodulation (Conference Presentation)