Real-time volumetric high-definition wide-field-of-view in-vivo cellular imaging requires micron-scale resolution in 3D.
Compactness of the handheld device and distortion-free images with cellular resolution are also critically required for onsite
use in clinical applications. By integrating a custom liquid lens-based microscope and a dual-axis MEMS scanner in
a compact handheld probe, Gabor-domain optical coherence microscopy (GD-OCM) breaks the lateral resolution limit of
optical coherence tomography through depth, overcoming the tradeoff between numerical aperture and depth of focus,
enabling advances in biotechnology. Furthermore, distortion-free imaging with no post-processing is achieved with a
compact, lightweight handheld MEMS scanner that obtained a 12-fold reduction in volume and 17-fold reduction in weight
over a previous dual-mirror galvanometer-based scanner. Approaching the holy grail of medical imaging – noninvasive
real-time imaging with histologic resolution – GD-OCM demonstrates invariant resolution of 2 μm throughout a volume
of 1 x 1 x 0.6 mm3, acquired and visualized in less than 2 minutes with parallel processing on graphics processing units.
Results on the metrology of manufactured materials and imaging of human tissue with GD-OCM are presented.
Cristina Canavesi, Andrea Cogliati, Adam Hayes, Patrice Tankam, Anand Santhanam, and Jannick P. Rolland, "3D wide field-of-view Gabor-domain optical coherence microscopy advancing real-time in-vivo imaging and metrology," Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100530Z (Presented at SPIE BiOS: January 31, 2017; Published: 17 February 2017); https://doi.org/10.1117/12.2252187.
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