Incorporating different data processing methods, Optical coherence tomography (OCT) has the ability for high-resolution micro-angiography and quantitative flow velocity measurement. However, OCT micro-angiography cannot provide quantitative measurement of flow velocity, and the velocity measurement based on Doppler OCT requires the determination of Doppler angles, which are difficult for whole vascular network. In this study, we report a relative standard deviation OCT (RSD-OCT) for the mapping of the flow velocity in a vascular network without the calculation of Doppler angle. From the theoretical analysis and experimental validation, the RSD-OCT is angle-independent and can quantify the flow velocity conveniently after a calibration.
Buyun Zhang, Jiang Zhu, Li Qi, Yiwei Gao, Tiancheng Huo, Zhuqing Zhu, and Zhongping Chen, "Quantitative angle-independent flow measurement using relative standard deviation OCT (Conference Presentation)," Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005312 (Presented at SPIE BiOS: January 31, 2017; Published: 19 April 2017); https://doi.org/10.1117/12.2251000.5371723149001.
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