In this study, we developed and applied highly-scattering large gold nanorods (LGNRs) and custom spectral detection
algorithms for high sensitivity contrast-enhanced optical coherence tomography (OCT). We were able to detect LGNRs
at a concentration as low as 50 pM in blood. We used this approach for noninvasive 3D imaging of blood vessels deep in
solid tumors in living mice. Additionally, we demonstrated multiplexed imaging of spectrally-distinct LGNRs that
enabled observations of functional drainage in lymphatic networks. This method, which we call MOZART, provides a
platform for molecular imaging and characterization of tissue noninvasively at cellular resolution.
Orly Liba, Elliott D. SoRelle, Debasish Sen, and Adam de la Zerda, "High sensitivity contrast enhanced optical coherence tomography for functional in vivo imaging," Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100531D (Presented at SPIE BiOS: January 31, 2017; Published: 17 February 2017); https://doi.org/10.1117/12.2248258.
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