We developed a quantitative optical coherence elastography (qOCE) system for nonlinear mechanical characterization of
biological tissues. The fiber-optic probe of the qOCE system had an integrated Fabry-Perot force sensor. To perform
mechanical characterization, the tissue was compressed uniaxially by the fiber-optic probe of the qOCE system. Using the
optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to simultaneously
quantify the force exerted to the tissue and the displacement of tissue. The quantification of the force was critical for
accurate assessment of the elastic behavior of tissue, because most biological tissues have nonlinear elastic behavior. We
performed qOCE characterization on tissue mimicking phantoms and biological tissues. Our results demonstrated the
capability of the qOCE system for linear and nonlinear assessment of tissue elasticity.
Yi Qiu, Farzana R. Zaki, Namas Chandra, Shawn A. Chester, and Xuan Liu, "Characterization of nonlinear elasticity for biological tissue using quantitative optical coherence elastography," Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005324 (Presented at SPIE BiOS: February 01, 2017; Published: 17 February 2017); https://doi.org/10.1117/12.2254042.
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