Progress in developing optical imaging for biomedical applications requires customizable and often complex objects known as "phantoms" for testing, evaluation, and calibration. This work demonstrates that 3D printing is an ideal method for fabricating such objects, allowing intricate inhomogeneities to be placed at exact locations in complex or anatomically realistic geometries, a process that is difficult or impossible using molds. We show printed mouse phantoms we have fabricated for developing deep tissue fluorescence imaging methods, and measurements of both their optical and mechanical properties. Additionally, we present a printed phantom of the human mouth that we use to develop an artery localization method to assist in oral surgery.
Brian Z. Bentz, Alfonso Costas, Vaibhav Gaind, Jose M. Garcia, and Kevin J. Webb, "3D printed optical phantoms and deep tissue imaging for in vivo applications including oral surgery," Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 1005607 (Presented at SPIE BiOS: January 28, 2017; Published: 14 March 2017); https://doi.org/10.1117/12.2253763.
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