Polarization of biological tissue reflects birefringent characteristics of tissue components such as collagenous and elastic fibers. Polarimetry imaging techniques have been widely explored for disease diagnosis and therapeutic guidance. However, no traceable standard is available for calibration and validation of the polarimetry devices, partially due to the lack of reliable and stable tissue-simulating phantoms that simulate tissue birefringence properties. We propose a new method to fabricate tissue simulating phantoms that simulate tissue scattering and polarization characteristics. The substrate of the phantoms are made of polydimethylsiloxane (PDMS). The PDMS material is mixed with sucrose to simulate optical rotation characteristics of chiral molecules in tissue. Titanum dioxide (TiO2 ) particles are used to simulate organelle scattering properties of tissue. An electrostatic spinning method produces thin filaments with designated orientation and polarization characteristics to simulate collagen and elastic fiber orientation in biological tissue.By adjusting the concentration of the scattering particles and the arrangements of the fibers, the produced phantoms present different polarization characteristics. The proposed tissue-simulating phantoms can be potentially used to validate and calibrate the polarimetry medical devices.
Haili Wang, Shu Wei Shen, Yingjie Qu, Mingzhai Z. Sun, Erbao Dong, Peng Fei Shao, and Ronald X. Xu, "Simulating tissue fiberation and polarization properties in solid phantoms (Conference Presentation)," Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 100560F (Presented at SPIE BiOS: January 29, 2017; Published: 20 April 2017); https://doi.org/10.1117/12.2253452.5371820519001.
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