It is of great interest to pattern biomaterials on the nanoscale and microscale to control diverse biomedical functions. We utilize soft lithographic technique to nanopattern poly (L-lactic acid) (PLLA) - a biodegradable and biocompatible polymer. We find that the PLLA surfaces nanopatterned with 750 nm pitch nanocup or nanocone arrays exhibit drug release rates 25-30% lower than that of the flat surface, which is counter-intuitive given the nanopattern-induced increase in their surface areas. Based on diffusion and microfluidic meniscus curvature minimization analyses, we attribute the decreased drug release rate to the incomplete wetting of the nanopatterned surface by the fluid.
Akshit Peer, Rabin Dhakal, Rana Biswas, and Jaeyoun Kim, "Nanoscale patterning of biopolymers for controlled microfluidic behavior and drug release (Conference Presentation)," Proc. SPIE 10061, Microfluidics, BioMEMS, and Medical Microsystems XV, 100610B (Presented at SPIE BiOS: January 29, 2017; Published: 24 April 2017); https://doi.org/10.1117/12.2253246.5371973264001.
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