Precise manipulation of particles and biological cells is an essential process in various biomedical research fields, industrial and clinical applications, which remains a very active research area in microfluidics. Among various force fields applied for microfluidic manipulations, acoustic waves have superior propagating properties in solids and fluids, which can readily enable non-contact cell manipulation in long operating distances. In addition, acoustic fields are advantageous to high power laser beams for non-contact optical tweezing in terms of biocompatibility, throughput and setup simplicity. Exploiting acoustic waves for fluid and cell manipulation in microfluidics has led to a newly emerging research area, acoustofluidics. In this presentation, I will talk about particle and cell manipulation in microfluidics using high frequency surface acoustic waves (SAW). In particular, I will discuss a unique design of a focused IDT (FIDT) structure, which is able to generate a highly localized SAW field on the order of 20 µm wide. This highly focused acoustic beam has an effective manipulation area size that is comparable to individual micron-sized particles. Here, I demonstrate the use of this highly localized SAW field for single particle level sorting using sub-millisecond pulses and selective capture of particles. Based on our research studies on acoustic particle manipulation, I envision that the merging of acoustics and microfluidics could enable various particle and cell manipulations needed in microfluidic applications.
Ye Ai, "Microfluidic particle manipulation using high frequency surface acoustic waves (Conference Presentation)," Proc. SPIE 10061, Microfluidics, BioMEMS, and Medical Microsystems XV, 100610G (Presented at SPIE BiOS: January 29, 2017; Published: 19 April 2017); https://doi.org/10.1117/12.2256276.5371973266001.
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