Imaging of small animals, especially rodents provides physiological, pathological, and phenotypical insights into the most relevant milieu—an intact, living system. Currently, non-optical small-animal wholebody imaging approaches lack either spatiotemporal resolution or functional contrasts, whereas pure optical imaging suffers from either shallow penetration (up to ~1 mm) or a poor resolution-to-depth ratio (~1/3). Here, we present a standalone system that breaks all the above limitations. Our system features high spatiotemporal resolution and deep penetration, and can capture anatomical and functional contrasts. We imaged mouse wholebody dynamics in real time with clear sub-organ anatomical and functional details.
Lei Li, Liren Zhu, Cheng Ma, Li Lin, Junjie Yao, Lidai Wang, Konstantin Maslov, Ruiying Zhang, Wanyi Chen, Junhui Shi, and Lihong V. Wang, "Imaging small animal whole-body dynamics by single-impulse panoramic photoacoustic computed tomography," Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100640M (Presented at SPIE BiOS: January 30, 2017; Published: 23 March 2017); https://doi.org/10.1117/12.2251593.
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