We will report on application of broadband coherent anti-Stokes Raman scattering microscopy1 to chemical mapping and characterization of resected prostate sections. While incidence of prostate cancer is very high, only a small fraction of prostate tumors will progress to advanced, metastatic disease and become dangerous, but prostatectomy and follow-on treatment have many undesirable potential side effects. Thus, it is important to predict which tumors will progress and which should be removed, but there is currently no highly reliable way to make such predictions. We will present a retrospective coherent Raman imaging study resected prostate sections focusing on locating tissue regions that present the highest diagnostic value with respect to lethal vs indolent disease. We intend that this provide a guide to optimal spectral sampling of these tissues to address this important clinical problem.
Marcus T. Cicerone and Charles H. Camp, "Broadband coherent Raman imaging as a potential diagnostic aid for histopathology (Conference Presentation)," Proc. SPIE 10069, Multiphoton Microscopy in the Biomedical Sciences XVII, 100690P (Presented at SPIE BiOS: January 30, 2017; Published: 24 April 2017); https://doi.org/10.1117/12.2256243.5380018889001.
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