DNA hybridization, where two single-stranded DNA molecules form duplex through sequence-specific interactions, is a fundamental biological process. To gain better understanding, sequence-specific detection of hybridization at the singlemolecule level has been instrumental and can find a wide variety of applications. Nanoporous gold nanoparticle (NPGNP) array chip features large specific surface area and high-density plasmonic field enhancement known as “hot-spots” that are attractive in nanoplasmonic sensor development. In this paper, we discuss results on detecting single-molecule DNA hybridization on functionalizing NPG-NP array chip with unique bio-recognition elements towards both high sensitivity and specificity.
Jingting Li, Fusheng Zhao, and Wei-Chuan Shih, "Single-molecule DNA hybridization on nanoporous gold nanoparticle array chip," Proc. SPIE 10075, Biophysics, Biology and Biophotonics II: the Crossroads, 1007505 (Presented at SPIE BiOS: January 28, 2017; Published: 22 February 2017); https://doi.org/10.1117/12.2253128.
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