A colorimetric biosensing system based on a porous silicon (PSi) rugate filter is demonstrated. Using an imaged-based technique that monitors RGB intensity, a spectral shift less than 0.25nm can be reliably detected. The porous silicon rugate filter demonstrates a sensitivity of 310 nm/RIU, which corresponds to a detection limit near 7×10-4 RIU. In this work, an external light source and camera are employed for proof-of-concept demonstration. By utilizing a smartphone camera LED and smartphone camera as the light source and detector, respectively, this system could serve as an effective, low-cost, point-of-care diagnostic tool.
Tengfei Cao, Yiliang Zhao, and Sharon M. Weiss, "A smartphone compatible colorimetric biosensing system based on porous silicon," Proc. SPIE 10077, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV, 1007713 (Presented at SPIE BiOS: February 02, 2017; Published: 22 February 2017); https://doi.org/10.1117/12.2250659.
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