Nanoplasmonic sensor has become a recent research focus due to its significant signal enhancement and robust signal transduction measured by various techniques. However, since the native gold surface does not have the capability to selectively bind target biomolecules, high molecular specificity has been a challenge. Nanoporous gold nanoparticle (NPG-NP) array chip showcases large specific surface area and high-density plasmonic field enhancement known as “hot-spots”. In this paper, we discuss strategies to enhance molecular specificity by functionalizing NPG-NP with unique bio-recognition elements towards both high sensitivity and specificity. A few examples will be given using existing and novel bio-recognition elements.
Fusheng Zhao, Suyan Qiu, Jingting Li, and Wei-Chuan Shih, "Sensitive and selective nanoplasmonic sensor by functionalized nanoporous gold nanoparticle array chip," Proc. SPIE 10080, Plasmonics in Biology and Medicine XIV, 1008006 (Presented at SPIE BiOS: January 30, 2017; Published: 17 February 2017); https://doi.org/10.1117/12.2253011.
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