We present a biomedical application of Digital Micro-mirror technologies by adapting the DLP4500 module for quasi real-time intraoperative tumor imaging. Fluorescence image guided surgery has been increasingly popular due to its ability to inform surgeons about tumor boundaries in real-time. We have extended this technique to provide 3D tomographic images of a tumor, by adapting a DLP4500 device to illuminate the surgical field with spatially modulated near-infrared (NIR) light. We combine the digital micro-mirror device (DMD) with two simultaneously triggered CMOS cameras to realize a spatial frequency domain imaging system. Spatial frequency domain imaging utilizes sinusoidally modulated illumination at different spatial frequencies and three different phases; corresponding signals are readily demodulated, and analyzed to derive a 3D fluorescence image. Our DMD device is commercially modified and equipped with high-power (5W) NIR diode laser. We present a brief discussion of data acquisition using DLP4500 module, and corrections for spatial inhomogeneity and gamma adjust in order to create linear/desired sinusoidal illumination of NIR light. We discuss results from a tissue phantom study and in-vivo experiments.
Sang Hoon Chong, Ashwin B. Parthasarathy, Venkaiah C. Kavuri, Frank A. Moscatelli, Sunil Singhal, and Arjun G. Yodh, "Intraoperative NIR diffuse optical tomography system based on spatially modulated illumination using the DLP4500 evaluation module (Conference Presentation)," Proc. SPIE 10117, Emerging Digital Micromirror Device Based Systems and Applications IX, 101170D (Presented at SPIE OPTO: January 31, 2017; Published: 3 May 2017); https://doi.org/10.1117/12.2253264.5397361483001.
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