Small animal positron emission tomography (PET) is a biological imaging technology that allows non-invasive interrogation of internal molecular and cellular processes and mechanisms of disease. New PET molecular probes with high specificity are under development to target, detect, visualize, and quantify subtle molecular and cellular processes associated with cancer, heart disease, and neurological disorders. However, the limited uptake of these targeted probes leads to significant reduction in signal. There is a need to advance the performance of small animal PET system technology to reach its full potential for molecular imaging. Our goal is to assemble a small animal PET system based on CZT detectors and to explore methods to enhance its photon sensitivity. In this work, we reconstruct an image from a phantom using a two-panel subsystem consisting of six CZT crystals in each panel. For image reconstruction, coincidence events with energy between 450 and 570 keV were included. We are developing an algorithm to improve sensitivity of the system by including multiple interaction events.
Shiva Abbaszadeh and Craig Levin, "Towards a high sensitivity small animal PET system based on CZT detectors (Conference Presentation)," Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101320C (Presented at SPIE Medical Imaging: February 13, 2017; Published: 2 May 2017); https://doi.org/10.1117/12.2254709.5361821873001.
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